About SYNTHIA™

SYNTHIA™ Retrosynthesis Software is a product of the Life Science business of Merck KGaA, Darmstadt, Germany.

Retrosynthesis is a widely used problem-solving technique in organic chemistry that begins with a target molecule and works iteratively backward to identify simpler starting compounds. SYNTHIA™ Retrosynthesis Software empowers organic chemists by expanding their expertise and liberating them from the time-consuming manual processes involved in synthetic route planning.
Engineered by organic chemists and computer scientists over the course of 21 years, SYNTHIA™ Retrosynthesis Software harnesses also the power of artificial intelligence (AI) in chemistry to curate information and predict reactions for computer-aided synthetic design of optimal synthetic routes.

Based on years of development as Chematica, published in August 2012, then further enhancement as SYNTHIA™ Retrosynthesis Software, this unique tool enables chemists to easily navigate through viable pathways that can be executed at the bench.
SYNTHIA™ Retrosynthesis Software is consistently enhanced by incorporating user feedback to refine every facet, including usability, security, scalability, and chemistry knowledge, thereby offering a more intuitive and functional experience.

With a catalog of over 12 million commercially available starting materials and building blocks, SYNTHIA™ provides access to a broad portfolio of available chemistry through the Sigma-Aldrich® web shop.